This course is designed to introduce students to the aetiology of human disease. Examples of common medical conditions will be used to illustrate the pathophysiology of various categories of human disease. Normal responses to disease in the body will be discussed as well as goals of medical therapies to address the pathology or support normal function. The use of medical imaging technologies and laboratory investigations to provide evidence in support of a clinical diagnosis will be introduced. Small group workshops exploring clinical cases will be used to introduce the process of clinical reasoning and evidence based decision making to students.

This course is co-taught with undergraduate students but assessed separately.

Learning Outcomes

Upon successful completion, students will have the knowledge and skills to:

Upon successful completion of this course, students will have the knowledge and skills to:

1. Describe the major mechanisms of human disease and the processes of compensation and repair in disease states and following injury;
2. Discuss common medical presentations in relationship to underlying pathologies; 
3. Interpret clinical pathology and anatomical pathology results in selected disease states;
4. Outline therapeutic aims and mechanisms in the treatment of human disease;
5. Describe the research methods and outcomes from selected scientific publications related to the course curriculum.

Examination Material or equipment

Nil

Staff Feedback

Students will be given feedback in the following forms in this course:

• written comments
• verbal comments
• feedback to whole class, groups, individuals, focus group etc

Student Feedback

ANU is committed to the demonstration of educational excellence and regularly seeks feedback from students. Students are encouraged to offer feedback directly to their Course Convener or through their College and Course representatives (if applicable). The feedback given in these surveys is anonymous and provides the Colleges, University Education Committee and Academic Board with opportunities to recognise excellent teaching, and opportunities for improvement. The Surveys and Evaluation website provides more information on student surveys at ANU and reports on the feedback provided on ANU courses.

Class Schedule

Week/Session	Summary of Activities	Assessment
1	T 22/7 Lecture: Introduction to Pathophysiology Overview of pathophysiology; Cell injury: causes, mechanisms, cellular adaptation, reversibility, aging, apoptosis and death. The lecture material will be supported by KuraCloud exercises to provide a study scaffold for revision of important concepts presented in the lecture.	Content from the lecture and KuraCloud resources are examinable in the final examination.
2	M 29/7: Laboratory. Hallmarks of cellular pathology. T 30/7 Lecture: Overview of the aetiology of human disease Categories of human disease: genetic disease vs, multifactorial disease, metabolic disease, degenerative diseases, inflammatory/autoimmune disease, neoplasm and cancer.	Content from week 2 will be assessed in the first online assessment (weeks 2,3,4) worth 5% (Due 23/8/19). Content from the lecture and KuraCloud resources are examinable in the final examination.
3	M 5 Aug: Laboratory. Gross pathology and histopathology features of benign and cancerous neoplasms of the skin and selected organs. T 6 Aug. Lecture: The immune system in health and disease Students will be introduced to the principles of the regulation of an immune response leading to protective effector functions of the immune response, the dark side of the immune system will be introduced in the context of hypersensitivity; atopy (allergy); self tolerance and autoimmunity, immune-surveillance, and immunodeficiency. David Kramer The lecture material will be supported by KuraCloud exercises to revise understanding of the components of immune system and to provide a study scaffold for revision of important concepts presented in the lecture.	Laboratory: Students will be required to submit a structured pathology report based on their observations in the laboratory. 5% (Due M 12/8/19) Content from week 3 will be assessed in the first online assessment (weeks 2,3,4) value = 5%. (Due F 23/8/19). Content from the lecture and KuraCloud resources are examinable in the final examination.
4	M 12 Aug . Team Based Learning activity. Students will be orientated to the principles of TBL and cased base learning. Clinical case studies will be employed to illustrate key concepts from the lecture. T 13 /8 Lecture: Haematology, haemostasis, inflammation and wound healing Students will be introduced to the processes involved in blood clotting, inflammation and wound healing. Disorders of blood, clotting disorders, and the pathological features of chronic inflammation will be introduced. The lecture material will be supported by KuraCloud exercises to revise understanding of the components of blood and to provide a study scaffold for revision of important concepts presented in the lecture.	M 12 August: Practical "pathology" report due by 5PM. Value = 5% The TBL will include formative feedback. Content from week 4 will be assessed in the first online assessment (weeks 2,3,4) due on Content from the lecture and KuraCloud resources are examinable in the final examination.
5	M 19 Aug Laboratory. Blood studies T 20 Aug. Lecture: Pathophysiology of the nervous system Students will be introduced to categories of neurological disorders and provided with illustrative examples of conditions affecting the peripheral and central nervous system together with an introduction to disorders affecting vision. The lecture material will be supported by KuraCloud exercises to revise understanding of the human nervous system, including major brain regions and to provide a study scaffold for revision of important concepts presented in the lecture.	Laboratory: Students will be required to submit a structured report based on their observations in the laboratory. (5% Due F 30/8/19) Content from week 5 will be assessed in the second online assessment (weeks 5,6,7) worth 5% (Due 27/09/19). Content from the lecture and KuraCloud resources are examinable in the final examination. F 23 August Online assessment due covering content from weeks 2,3,4 Value = 5%
6	M 26/8 Academic Skills Workshop on evaluating and summarizing literature. Students will be introduced to the requirements of the MEDN2002 written and group assignment. T 27/8 Lecture. Pathophysiology of the musculoskeletal system Students will be introduced to the pathophysiology of bone and muscle disorders, topics will include bone repair and remodeling and the role of calcium, osteoporosis, muscle power in neurological disorders and functional consequences of pathologies affecting the musculature system and rehabilitation. The lecture material will be supported by KuraCloud exercises to revise understanding of the components of musculoskeletal system and to provide a study scaffold for revision of important concepts presented in the lecture.	The workshop and lecture content are substantially linked to the individual and group assignment which will be due on 4/10 and in week 11, respectively. Presentation evening dates will be decided in consultation with the student cohort to minimise study disruption for other courses. Content from week 5 will be assessed in the second online assessment (weeks 5,6,7) worth 5% (Due 27/09/19). Content from the lecture and KuraCloud resources are examinable in the final examination.
7	M 16/9 TBL. Neurological and musculoskeletal cases. (Note this will include a clinical skills session where students will learn how to assess limb power and reflex functions) T 17/9 Lecture. Pathophysiology of the Endocrine system Students will be presented with an overview of the pathophysiology and consequences of selected endocrine system disorders (thyroid, adrenal gland, sex hormones, and energy metabolism), including an in depth treatment of Type 2 diabetes mellitus. The lecture material will be supported by KuraCloud exercises to revise understanding of the components of endocrine system and to provide a study scaffold for revision of important concepts presented in the lecture.	M 16 September: TBL will include a quiz at the start of the session which will be linked to the revision content provided in the KuraCloud sessions in weeks 5 and 6. value = FORMATIVE Content from week 7 will be assessed in the second online assessment (weeks 5,6,7) worth 5% (Due 27/09/19). Content from the lecture and KuraCloud resources are examinable in the final examination.
8	M 23/9 TBL. Endocrine case studies. (Note this will include a clinical skills session where students will learn how to assess BMI) T 24/9 Lecture Pathophysiology of the Cardiovascular system Students will be presented with an overview of the pathophysiology of the cardiovascular system including alteration of cardiovascular function across the life span, myocardial infarction, shock, heart failure. The lecture material will be supported by KuraCloud exercises to revise understanding of the components of cardiovascular system and to provide a study scaffold for revision of important concepts presented in the lecture.	M 23 September: TBL will include a quiz at the start of the session which will be linked to the revison content provided in the KuraCloud sessions in week 7. value = 2% Content from week will be assessed in the second online assessment (weeks 6,7,8) worth 5% (Due 11/10/19). Content from the lecture and KuraCloud resources are examinable in the final examination. F 27 September. Online assessment due covering weeks 5,6,7. Value = 5%
9	M 30/9 TBL. Cardiovascular case studies. (Note this will include a clinical skills session where students will learn how to assess ECG changes associated with selected case presentations) T 1/10 Lecture Pathophysiology of the Respiratory system Students will be presented with an overview of the pathophysiology of the respiratory system including alteration of respiratory function across the life span, respiratory infections, pneumothorax, restrictive and obstructive diseases, enviornmental and occupational hazards and neoplasms. The lecture material will be supported by KuraCloud exercises to revise understanding of the components of respiratory system and to provide a study scaffold for revision of important concepts presented in the lecture.	M 30 September: TBL will include a quiz at the start of the session which will be linked to the revision content provided in the KuraCloud sessions in week 8. value = 2% Content from week will be assessed in the third online assessment (weeks 9,10) worth 5% (Due 11/10/19). Content from the lecture and KuraCloud resources are examinable in the final examination. F 4 October Individual Essay due 10%
10	M 7/10 TBL. Respiratory case studies. T 8/10 Lecture Pathophysiology of the Renal system Students will be presented with an overview of the pathophysiology of the renal system including prerenal, intrarenal and post renal causes of renal injury; features of nephritic and nephrotic syndromes, formation and treatment of renal calculi, renal neoplasms. The lecture material will be supported by KuraCloud exercises to revise understanding of the components of renal system and to provide a study scaffold for revision of important concepts presented in the lecture.	M 7 October: TBL will include a quiz at the start of the session which will be linked to the revision content provided in the KuraCloud sessions in week 9. value = 2% Content from week 10 will be assessed in the third online assessment (weeks 10,11) worth 5% (Due 25/10/19). Content from the lecture and KuraCloud resouces are examinable in the final examination. F 11/10 Online assessment due covering weeks 8,9 Value = 5%
11	M 14/ 10 TBL Renal Case studies ( Note this will include tution in interpreting GFR and urinalysis) T 15/10 Lecture Pathophysiology of the gastrointestinal and hepatic systems Students will be presented with an overview of the pathophysiology of the GOT and heptobilliary systems including swallowing disorders, peptic ulcers, dumping syndrome, malabsorption syndromes, inflammatory bowel disease, ulcerative colitis, irritable bowel syndrome, alcoholic fatty liver, chirrosis, billiary obstuction and jaundice, infections and neoplasms. . The lecture material will be supported by KuraCloud exercises to revise understanding of the components of GIT and hepatic systems and to provide a study scaffold for revision of important concepts presented in the lecture.	M 14 October: TBL will include a quiz at the start of the session which will be linked to the revison content provided in the KuraCloud sessions in week10. value = 2% Group presentation of assignment. Date to be confirmed. value = 10% Content from week 11will be assessed in the third online assessment (weeks 10,11) worth 5% (Due 25/10/19). Content from the lecture and KuraCloud resources are examinable in the final examination.
12	M 21 /10 TBL GIT and Liver Case studies ( Note this will include tution in interpreting liver function tests and video presentations of endoscopy) T 22/10 Lecture Mental health, Stress and chronic disease states Students will be presented with an overview of the biological relationships between poor mental health, stress and the manifestation of chronic disease. This lecture will serve in part to revise some previously covered topics within selected systems.	M 21 October: TBL will include a quiz at the start of the session which will be linked to the revision content provided in the KuraCloud sessions in week 11. value = 2% F 25 October Online assessment four due covering weeks 10.11 Value = 5%

Tutorial Registration

Signup in week 1 will be done on Wattle

Assessment Summary

Assessment task	Value	Due Date	Return of assessment	Learning Outcomes
Lab report: Pathology	5 %	12/08/2019	26/08/2019	1,3
Lab report: Blood studies	5 %	30/08/2019	20/09/2019	1,3
Online progressive assessment weeks 2,3,4	5 %	23/08/2019	30/08/2019	1,2,3,4
Online progressive assessment weeks 5,6,7	5 %	27/09/2019	04/10/2019	1,2,3,4
Online progressive assessment weeks 8,9	5 %	11/10/2019	18/10/2019	1,2,3,4
Online progressive assessment weeks 10,11	5 %	25/10/2019	01/11/2019	1,2,3,4
TBL: Readiness preparation asessment 1	2 %	23/09/2019	30/09/2019	2,3,4
TBL: Readiness preparation assessment 2	2 %	30/09/2019	07/10/2019	2,3,4
TBL: Readiness preparation assessment 3	2 %	07/10/2019	14/10/2019	2,3,4
TBL: Readiness preparation assessment 4	2 %	14/10/2019	21/10/2019	2,3,4
TBL: Readiness preparation assessment 5	2 %	21/10/2019	28/10/2019	2,3,4
Individual Essay	10 %	04/10/2019	18/10/2019	4,5
Group CBL portfolio	10 %	17/10/2019	25/10/2019	4,5
End of Semester exam	40 %	31/10/2019	28/11/2019	1,2,3,4,5

* If the Due Date and Return of Assessment date are blank, see the Assessment Tab for specific Assessment Task details

Policies

ANU has educational policies, procedures and guidelines, which are designed to ensure that staff and students are aware of the University’s academic standards, and implement them. Students are expected to have read the Academic Misconduct Rule before the commencement of their course. Other key policies and guidelines include:

• Student Assessment (Coursework) Policy and Procedure
• Special Assessment Consideration Policy and General Information 
• Student Surveys and Evaluations
• Deferred Examinations
• Student Complaint Resolution Policy and Procedure

Assessment Requirements

The ANU is using Turnitin to enhance student citation and referencing techniques, and to assess assignment submissions as a component of the University's approach to managing Academic Integrity. For additional information regarding Turnitin please visit the ANU Online website. In rare cases where online submission using Turnitin software is not technically possible; or where not using Turnitin software has been justified by the Course Convener and approved by the Associate Dean (Education) on the basis of the teaching model being employed; students shall submit assessment online via ‘Wattle’ outside of Turnitin, or failing that in hard copy, or through a combination of submission methods as approved by the Associate Dean (Education). The submission method is detailed below.

Moderation of Assessment

Marks that are allocated during Semester are to be considered provisional until formalised by the College examiners meeting at the end of each Semester. If appropriate, some moderation of marks might be applied prior to final results being released.

Examination(s)

Please note, that where a date range is used in the Assessment Summary in relation to exams, the due date and return date indicate the approximate timeframe in which the exam will be held and results returned to the student (official end of Semester results released on ISIS). Students should consult the course wattle site and the ANU final examination timetable to confirm the date, time and venue of the exam.

Assessment Task 1

Lab report: Pathology

Instructions will be provided on Wattle.

Assessment Task 2

Lab report: Blood studies

Instructions will be provided on Wattle.

Assessment Task 3

Online progressive assessment weeks 2,3,4

Students will be required to develop responses to essay questions related to the previous weeks' content. This will include both revision of key learning objectives and extension of learnt concepts.

Assessment Task 4

Online progressive assessment weeks 5,6,7

Students will be required to develop responses to essay questions related to the previous weeks' content. This will include both revision of key learning objectives and extension of learnt concepts.

Assessment Task 5

Online progressive assessment weeks 8,9

Students will be required to develop responses to essay questions related to the previous weeks' content. This will include both revision of key learning objectives and extension of learnt concepts.

Assessment Task 6

Online progressive assessment weeks 10,11

Students will be required to develop responses to essay questions related to the previous weeks' content. This will include both revision of key learning objectives and extension of learnt concepts.

Assessment Task 7

TBL: Readiness preparation asessment 1

In class quiz on endocrine system

Assessment Task 8

TBL: Readiness preparation assessment 2

In class quiz on CVS system

Assessment Task 9

TBL: Readiness preparation assessment 3

in class quiz Respiratory system

Assessment Task 10

TBL: Readiness preparation assessment 4

in class quiz Renal system

Assessment Task 11

TBL: Readiness preparation assessment 5

in class quiz GIT Hepatic systems

Assessment Task 12

Individual Essay

Assessment Task 13

Group CBL portfolio

Students will present on different dates which will be discussed in class. The due date indicates the approximate date the first presentations are due, the return date indicates the end of the teaching period.

Assessment Task 14

End of Semester exam

The date range in the Assessment Summary indicates the start of the end of semester exam period and the date official end of semester results are released on ISIS. Please check the ANU final Examination Timetable http://www.anu.edu.au/students/program-administration/assessments-exams/examination-timetable to confirm the date, time and location exam.

Academic Integrity

Academic integrity is a core part of the ANU culture as a community of scholars. At its heart, academic integrity is about behaving ethically, committing to honest and responsible scholarly practice and upholding these values with respect and fairness.

The ANU commits to assisting all members of our community to understand how to engage in academic work in ways that are consistent with, and actively support academic integrity. The ANU expects staff and students to be familiar with the academic integrity principle and Academic Misconduct Rule, uphold high standards of academic integrity and act ethically and honestly, to ensure the quality and value of the qualification that you will graduate with.

The Academic Misconduct Rule is in place to promote academic integrity and manage academic misconduct. Very minor breaches of the academic integrity principle may result in a reduction of marks of up to 10% of the total marks available for the assessment. The ANU offers a number of online and in person services to assist students with their assignments, examinations, and other learning activities. Visit the Academic Skills website for more information about academic integrity, your responsibilities and for assistance with your assignments, writing skills and study.

Online Submission

You will be required to electronically sign a declaration as part of the submission of your assignment. Please keep a copy of the assignment for your records. Unless an exemption has been approved by the Associate Dean (Education) submission must be through Turnitin.

Hardcopy Submission

For some forms of assessment (hand written assignments, art works, laboratory notes, etc.) hard copy submission is appropriate when approved by the Associate Dean (Education). Hard copy submissions must utilise the Assignment Cover Sheet. Please keep a copy of tasks completed for your records.

Late Submission

Individual assessment tasks may or may not allow for late submission. Policy regarding late submission is detailed below:

• Late submission permitted. Late submission of assessment tasks without an extension are penalised at the rate of 5% of the possible marks available per working day or part thereof. Late submission of assessment tasks is not accepted after 10 working days after the due date, or on or after the date specified in the course outline for the return of the assessment item. Late submission is not accepted for take-home examinations.

Referencing Requirements

Accepted academic practice for referencing sources that you use in presentations can be found via the links on the Wattle site, under the file named “ANU and College Policies, Program Information, Student Support Services and Assessment”. Alternatively, you can seek help through the Students Learning Development website.

Returning Assignments

Lab reports and Online progressive assessments will be marked and returned with feedback. TBL assessments include immediate feedback in class.

The major individual assignment and the group assessment will be marked and returned with feedback.

Extensions and Penalties

Extensions and late submission of assessment pieces are covered by the Student Assessment (Coursework) Policy and Procedure. The Course Convener may grant extensions for assessment pieces that are not examinations or take-home examinations. If you need an extension, you must request an extension in writing on or before the due date. If you have documented and appropriate medical evidence that demonstrates you were not able to request an extension on or before the due date, you may be able to request it after the due date.

Resubmission of Assignments

Not allowed

Privacy Notice

The ANU has made a number of third party, online, databases available for students to use. Use of each online database is conditional on student end users first agreeing to the database licensor’s terms of service and/or privacy policy. Students should read these carefully. In some cases student end users will be required to register an account with the database licensor and submit personal information, including their: first name; last name; ANU email address; and other information.
In cases where student end users are asked to submit ‘content’ to a database, such as an assignment or short answers, the database licensor may only use the student’s ‘content’ in accordance with the terms of service – including any (copyright) licence the student grants to the database licensor. Any personal information or content a student submits may be stored by the licensor, potentially offshore, and will be used to process the database service in accordance with the licensors terms of service and/or privacy policy.
If any student chooses not to agree to the database licensor’s terms of service or privacy policy, the student will not be able to access and use the database. In these circumstances students should contact their lecturer to enquire about alternative arrangements that are available.

Distribution of grades policy

Academic Quality Assurance Committee monitors the performance of students, including attrition, further study and employment rates and grade distribution, and College reports on quality assurance processes for assessment activities, including alignment with national and international disciplinary and interdisciplinary standards, as well as qualification type learning outcomes.

Since first semester 1994, ANU uses a grading scale for all courses. This grading scale is used by all academic areas of the University.

Support for students

The University offers students support through several different services. You may contact the services listed below directly or seek advice from your Course Convener, Student Administrators, or your College and Course representatives (if applicable).

• ANU Health, safety & wellbeing for medical services, counselling, mental health and spiritual support
• ANU Diversity and inclusion for students with a disability or ongoing or chronic illness
• ANU Dean of Students for confidential, impartial advice and help to resolve problems between students and the academic or administrative areas of the University
• ANU Academic Skills and Learning Centre supports you make your own decisions about how you learn and manage your workload.
• ANU Counselling Centre promotes, supports and enhances mental health and wellbeing within the University student community.
• ANUSA supports and represents undergraduate and ANU College students
• PARSA supports and represents postgraduate and research students