This course will teach the biology of the Immune system and apply this knowledge to an understanding of human disease and basic immunological research. In a series of lectures, seminars and tutorials, it will provide a fundamental understanding of the immune response in its entirety, then build on this foundation to study the application of immunological knowledge to human disease (autoimmunity, immunodeficiency, allergy, neoplasia), how the immune system can be manipulated by directed therapeutics, how changes that accompany immunologic disease can be measured in the diagnostic laboratory, and how knowledge of the immune system can be extended by basic research. The course will help achieve an academic understanding of the immune system for future practice in the biological sciences including medicine (where the foundation principles in this course will be invaluable) or as a prelude to applied research into human disease, including animal models.

Note:  Graduate students attend joint classes with undergraduates but are assessed separately.

Learning Outcomes

Upon successful completion, students will have the knowledge and skills to:

On satisfying the requirements of this course, students will have the knowledge and skills to:

1. Demonstrate detailed knowledge of how the immune system normally responds to infection.
2. Apply knowledge and incorporate principles to show how aberrations in immunoregulation underlie autoimmunity, immunodeficiency, allergy and cancer.
3. Explain how such aberrations can be measured in the laboratory and potentially corrected by directed therapeutics.
4. Acquire, analyse and interpret experimental data on research in immunology
5. Critically evaluate the current literature to assimilate views on the latest findings

Additional Course Costs

Personal Protective Equipment (PPE) is required in all wet labs. Lab coats and safety glasses can be purchased from the Harry Hartog Bookshop.

Examination Material or equipment

Only writing instruments will be allowed into the examination hall.

Required Resources

Kenneth Murphy and Casey Weaver. Janeway’s Immunobiology (9th Edition), Garland Science, 2016. ISBN 978-0-8153-4505-3

Recommended Resources

1. Abbas, AK, Lichtman, AH and Pillai S. Cellular and Molecular Immunology (8th Edition), Elsevier Saunders, 2015. (eBook at: http://library.anu.edu.au/record=b3609426)

2. Parham P. The Immune System (4th Edition), Garland Science, 2014

Call number: QR181.P335 2015, Hancock Library

3. Smith P, MacDonald T and Blumberg R. Principles of Mucosal Immunology (1st edition) Garland Science, 2012. Call number: QR185.9.M83 P75 2013

4. Kaufmann SHE, Rouse BT and Sacks DL. Immune Response to Infection, ASM Press, 2011 (eBook at http://library.anu.edu.au/record=b3451369); Call number: QR186.I445 2011eb

Staff Feedback

Students will be given feedback in the following forms in this course:

• Written comments
• Verbal comments

Feedback to whole class, tutorial groups and individuals where appropriate.

Student Feedback

ANU is committed to the demonstration of educational excellence and regularly seeks feedback from students. Students are encouraged to offer feedback directly to their Course Convener or through their College and Course representatives (if applicable). The feedback given in these surveys is anonymous and provides the Colleges, University Education Committee and Academic Board with opportunities to recognise excellent teaching, and opportunities for improvement. The Surveys and Evaluation website provides more information on student surveys at ANU and reports on the feedback provided on ANU courses.

Other Information

Where an assignment is formed of a number of activities, the date range indicates the due date for the first component and the return date of the final component. Further information is provided in the assessment section of the class summary, and details are provided on the course wattle site.

Class Schedule

Week/Session	Summary of Activities	Assessment
1	COURSE SCHEDULE is tentative and subject to change Lectures, Seminars, Tutorials: Topics as below. Timetable will be posted and updated continually: please refer to Wattle for updated schedules.
2	Lectures Lectures will constitute the curriculum of the course, and will be the main focus of the written examination. Topics for the core lectures are: Course introduction and welcome Basics of the Immune response Innate immunity I - III Immunoglobulin and applications B cells I Pre-antigenic B cells II Post-antigenic T cells IT cells II MHC: structure, function, genetics, Ag presentation T-cell tolerance Lymphocyte migration Autoimmunity — mechanisms Autoimmune diseases Mucosal immunity Signalling pathways in the immune system I - II Immunodeficiency Allergy Interventions for human immunological disease Overview of the Immune system - SUMMARY Interventions for human immunological disease	Assessment task 5
3	Seminars Seminars are designed to enhance, reinforce and extend the concepts in the lectures, and will be evaluated by short on-line questionnaires. Topics for the seminars are: Flow cytometry—Analysis with FlowJo Flow cytometry—Principles B cell regulation in the germinal centre B cells and autoimmunity Dissecting intracellular signalling pathways in the laboratory Immune response to viruses Murine immune system - mouse models of disease Research methodology Flow cytometry—Advanced applications and analysis Immune response to extracellular and intracellular bacteria Vaccinology Immune response to parasites and fungi Research directions - immunodeficiency Diagnostic laboratory - Autoimmunity	Assessment task 4
4	Flow cytometry Practical: Student will prepare a (mouse) cell suspension and analysis and are required to identify its tissue of origin using multicolour Flow Cytometry, including analysis of listmode/FCS data offline. Demonstration of Cell Sorting in the Flow Cytometry Unit, JCSMR	Assessment task 1
5	Small group tutorials. The cohort of students will be divided into four groups, and each will be allocated a demonstrator who will continue throughout the semester. Activities in these groups will include: Focus topics. These will be allocated to students, who will present them in small groups to demonstrators, along with a 1-page summary, over 10+5 minutes. Topics will be specific, and designed to provide some ‘fine print’ to the more general didactic lectures (eg “Toll like receptors”, “MBL”, IL-1 etc). Marked by demonstrators, 10% of the final mark. Journal presentation. Recent research papers will be allocated to pairs of students who will present a summary to their group. 20+10 minutes. Tutorials. Questions will be distributed and worked through with the convenors	Assessment tasks 2 and 3

Assessment Summary

Assessment task	Value	Due Date	Return of assessment	Learning Outcomes
Flow cytometry prac report	15 %	*	*	1,2,3,4
Topic presentation	10 %	*	*	5
Immunodeficiency presentation	10 %	*	*	5
Journal Presentation	10 %	*	*	5
On-line questions (three questions per lecture)	15 %	*	*	1,2,3,4
Written assignment	15 %	*	*	1,2,3,4,5
Final Exam	25 %	05/11/2020	03/12/2020	1,2,3,4

* If the Due Date and Return of Assessment date are blank, see the Assessment Tab for specific Assessment Task details

Policies

ANU has educational policies, procedures and guidelines, which are designed to ensure that staff and students are aware of the University’s academic standards, and implement them. Students are expected to have read the Academic Misconduct Rule before the commencement of their course. Other key policies and guidelines include:

• Student Assessment (Coursework) Policy and Procedure
• Special Assessment Consideration Policy and General Information 
• Student Surveys and Evaluations
• Deferred Examinations
• Student Complaint Resolution Policy and Procedure

Assessment Requirements

The ANU is using Turnitin to enhance student citation and referencing techniques, and to assess assignment submissions as a component of the University's approach to managing Academic Integrity. For additional information regarding Turnitin please visit the Academic Integrity . In rare cases where online submission using Turnitin software is not technically possible; or where not using Turnitin software has been justified by the Course Convener and approved by the Associate Dean (Education) on the basis of the teaching model being employed; students shall submit assessment online via ‘Wattle’ outside of Turnitin, or failing that in hard copy, or through a combination of submission methods as approved by the Associate Dean (Education). The submission method is detailed below.

Moderation of Assessment

Marks that are allocated during Semester are to be considered provisional until formalised by the College examiners meeting at the end of each Semester. If appropriate, some moderation of marks might be applied prior to final results being released.

Participation

Students are expected to actively participate through the course, particularly with respect to attendance/engagement at lectures, pracs and tutorials, including on-line discussion via Wattle. Attendance at the practical, the tutorials, and Research Directions lectures is a course requirement and will be recorded.

To pass this course you must achieve an overall mark of 50% or more, including all assessments. Students are not required to pass the written exam. Students who achieve a final result of 45-49% for the course will be offered supplementary assessment.

Refer to ANU Supplementary exams rules at the following site: http://www.anu.edu.au/students/program-administration/assessments-exams/supplementary-exams.

If the supplementary examination is passed, the final result will be 50PS. If the supplementary examination is failed the final result will be N.

Examination(s)

The date range in the Assessment Summary indicates the start of the end of semester exam period and the date official end of semester results are released on ISIS. Please check the ANU final Examination Timetable http://www.anu.edu.au/students/program-administration/assessments-exams/examination-timetable to confirm the date, time and location exam.

Assessment Task 1

Flow cytometry prac report

Analysis of FCS files (generated in prac) using dedicated software, and complete short answer questions applicable to that analysis.

Word limit (where applicable): 2 pages, per supplied template with font restrictions

Presentation requirements: 2-page report.

Due: 8 am Monday Week 4

Estimated return date: It is intended that the marked assignment will be returned within two weeks from submission. The exact return date will be posted on the Wattle site

Hurdle Assessment requirements (where applicable): No

Individual Assessment in Group Tasks (where applicable): No

Assessment Task 2

Topic presentation

Preparation of 1-page summary of a topic to be individually allocated, to be presented to fellow students in a tutorial setting.

Assessment Rubrics: will be posted with details of the assessment.

Word limit (where applicable): Your summary should be in 12 point Times New Roman, 1.5 line spaced, and occupy no more than one A4 page with 2 cm margins (references may spill over to second page)

Presentation requirements: Presented to fellow students in tutorial, over 10 minutes, and 5 minutes discussion.

Due: Present in tutorials, as rostered

Estimated return date: It is intended that the marked assignment will be returned within two weeks from submission. The exact return date will be posted on the Wattle site.

Assessment Task 3

Immunodeficiency presentation

Preparation of 1-page summary of an immunodeficiency topic to be individually allocated, to be presented to fellow students in a tutorial setting.

Assessment Rubrics: will be posted with details of the assessment.

Word limit (where applicable): Your summary should be in 12 point Times New Roman, 1.5 line spaced, and occupy no more than one A4 page with 2 cm margins (references may spill over to second page)

Presentation requirements: Presented to fellow students in tutorial, over 10 minutes, and 5 minutes discussion.

Due: Present in tutorials, as rostered

Estimated return date: It is intended that the marked assignment will be returned within two weeks from submission. The exact return date will be posted on the Wattle site

Assessment Task 4

Journal Presentation

A journal article will be allocated to pairs of students, who will analyse that article, and present it to their tutorial group as if at a plenary of a scientific conference.

Assessment Rubrics: will be posted with details of the assessment.

Word limit (where applicable): n/a

Presentation requirements: 20 minutes, with 10 minutes discussion.

Due: Present in tutorials, as rostered

Estimated return date: Weeks 8 – 10, depending on group

Assessment Task 5

On-line questions (three questions per lecture)

Three multiple choice questions will be posted on Wattle within a day of a seminar. Students are required to answer the questions within 1 week of posting.

Estimated return date: 8 am the Monday following the lecture

Due: 1 week following lecture

There are multiple question sets due during the session. It is intended that the marked questions sets will be returned the Monday following the lecture. Further details can be found on the Course Wattle site.

Students are expected to contribute on an on-going basis throughout the semester. The date range for this task comprises the start of the semester and the date final results are published on ISIS.

Assessment Task 6

Written assignment

Details of task: You are provided with a recent publication. You need to analyse this paper carefully in the context of current knowledge, and prepare a ‘News and Views’ commentary of between 2000 and 2500 words, succinctly summarizing the major findings of the paper in the context of current knowledge, identifying and discussing any pitfalls in the paper, as well as outlining how the findings contribute to what is already known

Assessment Rubrics: will be posted with details of the assessment.

Word limit (where applicable): 2000 and 2500 words

Presentation requirements: n/a

Due: 8 am Tuesday Week 10

Estimated return date: End of semester

Assessment Task 7

Final Exam

Details: Students will be required to answer 8 short-answer questions (approximately 1 page each) over 2 hrs 30 minutes.

Assessment Rubrics: will be posted.

Academic Integrity

Academic integrity is a core part of the ANU culture as a community of scholars. At its heart, academic integrity is about behaving ethically, committing to honest and responsible scholarly practice and upholding these values with respect and fairness.

The ANU commits to assisting all members of our community to understand how to engage in academic work in ways that are consistent with, and actively support academic integrity. The ANU expects staff and students to be familiar with the academic integrity principle and Academic Misconduct Rule, uphold high standards of academic integrity and act ethically and honestly, to ensure the quality and value of the qualification that you will graduate with.

The Academic Misconduct Rule is in place to promote academic integrity and manage academic misconduct. Very minor breaches of the academic integrity principle may result in a reduction of marks of up to 10% of the total marks available for the assessment. The ANU offers a number of online and in person services to assist students with their assignments, examinations, and other learning activities. Visit the Academic Skills website for more information about academic integrity, your responsibilities and for assistance with your assignments, writing skills and study.

Online Submission

You will be required to electronically sign a declaration as part of the submission of your assignment. Please keep a copy of the assignment for your records. Unless an exemption has been approved by the Associate Dean (Education) submission must be through Turnitin.

Hardcopy Submission

For some forms of assessment (hand written assignments, art works, laboratory notes, etc.) hard copy submission is appropriate when approved by the Associate Dean (Education). Hard copy submissions must utilise the Assignment Cover Sheet. Please keep a copy of tasks completed for your records.

Late Submission

Individual assessment tasks may or may not allow for late submission. Policy regarding late submission is detailed below:

• Late submission permitted. Late submission of assessment tasks without an extension are penalised at the rate of 5% of the possible marks available per working day or part thereof. Late submission of assessment tasks is not accepted after 10 working days after the due date, or on or after the date specified in the course outline for the return of the assessment item. Late submission is not accepted for take-home examinations.

Referencing Requirements

Accepted academic practice for referencing sources that you use in presentations can be found via the links on the Wattle site, under the file named “ANU and College Policies, Program Information, Student Support Services and Assessment”. Alternatively, you can seek help through the Students Learning Development website.

Returning Assignments

The exact return date will be posted on the Wattle site

Extensions and Penalties

Extensions and late submission of assessment pieces are covered by the Student Assessment (Coursework) Policy and Procedure. Extensions may be granted for assessment pieces that are not examinations or take-home examinations. If you need an extension, you must request an extension in writing on or before the due date. If you have documented and appropriate medical evidence that demonstrates you were not able to request an extension on or before the due date, you may be able to request it after the due date.

Resubmission of Assignments

Resubmission of assignments will not be allowed

Privacy Notice

The ANU has made a number of third party, online, databases available for students to use. Use of each online database is conditional on student end users first agreeing to the database licensor’s terms of service and/or privacy policy. Students should read these carefully. In some cases student end users will be required to register an account with the database licensor and submit personal information, including their: first name; last name; ANU email address; and other information.
In cases where student end users are asked to submit ‘content’ to a database, such as an assignment or short answers, the database licensor may only use the student’s ‘content’ in accordance with the terms of service – including any (copyright) licence the student grants to the database licensor. Any personal information or content a student submits may be stored by the licensor, potentially offshore, and will be used to process the database service in accordance with the licensors terms of service and/or privacy policy.
If any student chooses not to agree to the database licensor’s terms of service or privacy policy, the student will not be able to access and use the database. In these circumstances students should contact their lecturer to enquire about alternative arrangements that are available.

Distribution of grades policy

Academic Quality Assurance Committee monitors the performance of students, including attrition, further study and employment rates and grade distribution, and College reports on quality assurance processes for assessment activities, including alignment with national and international disciplinary and interdisciplinary standards, as well as qualification type learning outcomes.

Since first semester 1994, ANU uses a grading scale for all courses. This grading scale is used by all academic areas of the University.

Support for students

The University offers students support through several different services. You may contact the services listed below directly or seek advice from your Course Convener, Student Administrators, or your College and Course representatives (if applicable).

• ANU Health, safety & wellbeing for medical services, counselling, mental health and spiritual support
• ANU Diversity and inclusion for students with a disability or ongoing or chronic illness
• ANU Dean of Students for confidential, impartial advice and help to resolve problems between students and the academic or administrative areas of the University
• ANU Academic Skills and Learning Centre supports you make your own decisions about how you learn and manage your workload.
• ANU Counselling Centre promotes, supports and enhances mental health and wellbeing within the University student community.
• ANUSA supports and represents undergraduate and ANU College students
• PARSA supports and represents postgraduate and research students