Chemistry has changed rapidly over the past decades and techniques that were once exclusively applied to small molecules are now routinely used with larger molecules, such as proteins. This course will be the first introduction of students to the field of chemical biology,  which spans chemistry, biology and physics. Biological molecules and systems are analysed and modified using chemical principles and techniques.

Learning Outcomes

Upon successful completion, students will have the knowledge and skills to:

Upon successful completion of this course, students will have the knowledge and skills to:
1. Advanced understanding of the physical and chemical principles that underpin biology
2. Understanding of physico-chemico basis for how and why drugs work
3. Capability to analyse enzyme kinetic and receptor binding data
4. Understanding of modern synthetic techniques for drug development
5. Experience with techniques for protein analysis,
6. Understanding of advanced biophysical techniques for protein analysis, including the capacity to discuss their relative merits and interpret data from those techniques,
7. Capability to synthesise a small molecule inhibitor
8. Understanding of the role of chemical biology in industry and commerce

Research-Led Teaching

Chemistry is essentially an experimental science. The laboratory program consists of a variety of experimental exercises designed to:

1. illustrate and develop competence in a range of chemical and biochemical techniques and manipulative skills.
2. emphasise the importance of a quantitative analytical approach to biochemical systems.
3. develop an awareness of the scope and limitation of experimental observation and accuracy.
4. illustrate chemical and biological topics, principles and concepts.

Required Resources

The prescribed textbook is: The Molecules of Life: Physical and Chemical Principles by Kuriyan, Konforti and Wemmer, 1st Edition.

The text book is available as an ebook and as a hard copy.

The hardcopy can be purchased from the Garland web page: http://www.garlandscience.com/product/isbn/9780815341888

A copy is available in the chemistry drop-in centre and in the University library.

This text forms the basis of the course, and many of the examples, illustrations, and exercises used will be taken directly from them. It should be used extensively and intelligently to support and enhance your understanding of the subject. In addition, a molecular model kit can also be purchased from the Research School of Chemistry.

Recommended Resources

Course Website – online resources

Login using your student ID and password at http://wattle.anu.edu.au to find the course websites for CHEM2211. You will be automatically added to these websites the evening

after you have enrolled in the courses via ISIS. If you cannot see the online site/s, please contact the Undergraduate Chemistry Administrator (rsc.teaching@anu.edu.au). These course websites will contain lecture material, extra resources, self-test questions and discussion board postings. Please check these sites at least once per week for important notices.

Staff Feedback

Students will be given feedback in the following forms in this course:

• written comments
• verbal comments
• feedback to whole class, groups, individuals, focus group etc

Student Feedback

ANU is committed to the demonstration of educational excellence and regularly seeks feedback from students. Students are encouraged to offer feedback directly to their Course Convener or through their College and Course representatives (if applicable). The feedback given in these surveys is anonymous and provides the Colleges, University Education Committee and Academic Board with opportunities to recognise excellent teaching, and opportunities for improvement. The Surveys and Evaluation website provides more information on student surveys at ANU and reports on the feedback provided on ANU courses.

Other Information

For Chemistry students the definitions and penalties are set out below.

Plagiarism: Plagiarism is copying, paraphrasing or summarising, without acknowledgement, any work of another person with the intention of representing this as the student’s own work. This remains plagiarism whether or not it is with the knowledge or consent of that other person.

 

Direct copying falls under the definition of plagiarism. When students work together, they must be sure to write independently, and not in collaboration with another student or group of students. The purpose of assessment is to evaluate each student’s mastery of skills and knowledge. It is acceptable for students to compare and discuss results of experiments of essay concepts, but written work must reflect individual effort and all written work must be the student’s own.

 

To avoid plagiarism students must correctly acknowledge the work of others. If students transcribe, quote, paraphrase or summarise the ideas obtained form the work of others, they must identify the source and author of the original work and provide a bibliography.

 

Serious, and in particular repeated instances of academic dishonesty, constitute misconduct and need to be dealt with under the ANU Discipline Rules.

 

Multiple Submissions (Recycling): Recycling is the submission of work for assessment, which has been previously presented by the same student for another assessment either at ANU or elsewhere. In some cases, lecturers will specifically allow this practice. If no specific provision is made then it constitutes academic dishonesty when assessment is submitted a second or subsequent time.

 

Serious and, in particular repeated instances of academic dishonesty, constitute misconduct and need to be dealt with under the ANU Discipline Rules.

 

Fabrication or Falsification of Data: Fabrication of research is the representation of data, observation or other research activity as genuine, comprehensive and/or original when it has been arrived at through other means. These may be inventing data, using data gathered by other researchers without acknowledgement, or deliberately omitting data to obtain the apparently desired results.

 

Any data presented as the result of laboratory work (in the form of drawings, graphs, tables or written work) must be true and representative of your findings.

Serious and, in particular repeated instances of academic dishonesty, constitute misconduct and need to be dealt with under the ANU Discipline Rules.

 

Collusion: Collusion is the representation of original work of several persons as the work of a single student. Collusion needs to be distinguished from collaboration, defined for the purposes of this document as work jointly undertaken and produced within permissible parameters. Another form of collusion involves representing the work of one good student as the work of several individual students, in for example the situation where students A, B and C pay student D to do the assignment and give them each a copy, which they then rephrase and submit as their own.

 

Serious and, in particular repeated instances of academic dishonesty, constitute misconduct and need to be dealt with under the ANU Discipline Rules.

 

Cheating: Cheating in this code means the breach of rules regarding formal examinations, or dishonest practice in informal examination, tests or other assessments. Examples include the use of prohibited material or equipment for unfair advantage, consultation with other persons during the course or the assessment where this is prohibited.

 

Serious and, in particular repeated instances of academic dishonesty constitute misconduct and need to be dealt with under the ANU Discipline Rules.

Class Schedule

Week/Session	Summary of Activities	Assessment
1	3 lectures by Colin Jackson
2	3 lectures by Colin Jackson, 1 lab (Easton intro lab)
3	2 lectures by Chris Easton, 1 lab (Easton lab 1)
4	3 lectures by Chris Easton, 1 lab (Easton lab 2)
5	3 lectures by Chris Easton, 1 lab (Easton lab 3)
6	3 lectures by Chris Easton
7	1 lecture by Chris Easton	Mid Semester Exam
8	2 lectures by John Carver, 1 lab (Carver lab)
9	3 lectures by John Carver
10	1 lecture by John Carver, 2 lectures by Megan O'Mara, 1 lab (O'Mara lab 1)
11	3 lectures by Megan O'Mara, 1 lab (O'Mara computational lab 2)
12	2 lectures by Megan O'Mara

Tutorial Registration

There will be a number of laboratory class groups operating on Thursday and Friday afternoons. You will be asked to select a laboratory stream on the CHEM2211 WATTLE homepage http://wattle.anu.edu.au. Discuss any timetable clashes immediately with the Convenor.

PLEASE NOTE: A student who consumes any laboratory chemicals or compounds that have been prepared in the laboratory will be excluded from the course.

Assessment Summary

Assessment task	Value	Due Date	Return of assessment	Learning Outcomes
Topic Exam 1	35 %	22/04/2019	26/04/2019	1,2,3,4,5
Topic Exam 2	35 %	06/06/2019	04/07/2019	1,2,3,4,5
Attendance at ALL laboratory sessions and submission of ALL laboratory reports	30 %	25/02/2019	31/05/2019	6,7,8

* If the Due Date and Return of Assessment date are blank, see the Assessment Tab for specific Assessment Task details

Policies

ANU has educational policies, procedures and guidelines, which are designed to ensure that staff and students are aware of the University’s academic standards, and implement them. Students are expected to have read the Academic Misconduct Rule before the commencement of their course. Other key policies and guidelines include:

• Student Assessment (Coursework) Policy and Procedure
• Special Assessment Consideration Policy and General Information 
• Student Surveys and Evaluations
• Deferred Examinations
• Student Complaint Resolution Policy and Procedure

Assessment Requirements

The ANU is using Turnitin to enhance student citation and referencing techniques, and to assess assignment submissions as a component of the University's approach to managing Academic Integrity. For additional information regarding Turnitin please visit the ANU Online website. In rare cases where online submission using Turnitin software is not technically possible; or where not using Turnitin software has been justified by the Course Convener and approved by the Associate Dean (Education) on the basis of the teaching model being employed; students shall submit assessment online via ‘Wattle’ outside of Turnitin, or failing that in hard copy, or through a combination of submission methods as approved by the Associate Dean (Education). The submission method is detailed below.

Moderation of Assessment

Marks that are allocated during Semester are to be considered provisional until formalised by the College examiners meeting at the end of each Semester. If appropriate, some moderation of marks might be applied prior to final results being released.

Participation

The Research School of Chemistry considers the laboratory component of all courses to be an integral part of each course and as such all laboratory sessions are compulsory. It is therefore the policy of the Research School of Chemistry that students will attend all laboratory classes scheduled for any course. Absences must be notified (in advance, if possible) to the course convenor, and accompanied by adequate and appropriate documentation justifying the absence.

Penicillin laboratory

Please be advised that the practical laboratory sessions involve working with penicillins. An alternative assessment stream will be made available to those with a history of penicillin allergy (doctor’s certificate required).

Three of the laboratory sessions involve penicillins. These are to be held in weeks 3 - 5, designated Easton labs 1-3. For students with a penicillin allergy that prevents their participation in these classes (doctor's certificate required), the following alterate assessment is available. Those students should obtain results from others in the class or from the laboratory demonstrators and use them to complete laboratory reports in the usual way. In addition, they should, with the final three reports, provide a critical review of approximately 1500-2000 words on "Fleming, Florey and Chain, and the history of penicillin". The review should include a title, abstract and bibliography as well as the main text.

Examination(s)

Please note, that where a date range is used in the Assessment Summary in relation to exams, the due date and return date indicate the approximate timeframe in which the exam will be held and results returned to the student (official end of Semester results released on ISIS). Students should consult the course wattle site and the ANU final examination timetable to confirm the date, time and venue of the exam.

Assessment Task 1

Topic Exam 1

The first topic exam will assess lecture material covered in the first 18 lectures (given by Jackson and Easton). This exam will alert students to the standards expected and give valuable early feedback on progress.

Please check the ANU final Examination Timetable to confirm the date, time and location of the mid semester exam.

Assessment Task 2

Topic Exam 2

The second topic exam will assess lecture material covered in the last 14 lectures (given by Carver and O'Mara).

Please check the ANU final Examination Timetable to confirm the date, time and location of the end of semester exam.

Assessment Task 3

Attendance at ALL laboratory sessions and submission of ALL laboratory reports

Six laboratory reports must be submitted, one for each practical.

Each will be worth 5% of the total grade.

Model reports will be provided on WATTLE to alert students to the standard expected and the normal format.

Attendance at the Introductory Laboratory session is also obligatory.

The date range for these tasks indicates the approximate due date for the first report, and the approximate return date for the last report. There are 6 reports due over the semester.

Academic Integrity

Academic integrity is a core part of our culture as a community of scholars. At its heart, academic integrity is about behaving ethically. This means that all members of the community commit to honest and responsible scholarly practice and to upholding these values with respect and fairness. The Australian National University commits to embedding the values of academic integrity in our teaching and learning. We ensure that all members of our community understand how to engage in academic work in ways that are consistent with, and actively support academic integrity. The ANU expects staff and students to uphold high standards of academic integrity and act ethically and honestly, to ensure the quality and value of the qualification that you will graduate with. The University has policies and procedures in place to promote academic integrity and manage academic misconduct. Visit the following Academic honesty & plagiarism website for more information about academic integrity and what the ANU considers academic misconduct. The ANU offers a number of services to assist students with their assignments, examinations, and other learning activities. The Academic Skills and Learning Centre offers a number of workshops and seminars that you may find useful for your studies.

Online Submission

You will be required to electronically sign a declaration as part of the submission of your assignment. Please keep a copy of the assignment for your records. Unless an exemption has been approved by the Course Convenor submission must be through Turnitin.

Hardcopy Submission

For some forms of assessment (hand written assignments, laboratory notes, etc.) hard copy submission is appropriate when approved by the Course Convenor. Hard copy submissions must utilise the Assignment Cover Sheet. Please keep a copy of tasks completed for your records.

Late Submission

Late submission permitted. Late submission of assessment tasks without an extension are penalised at the rate of 5% of the possible marks available per working day or part thereof. Late submission of assessment tasks is not accepted after 10 working days after the due date, or on or after the date specified in the course outline for the return of the assessment item. Late submission is not accepted for take-home examinations.

Referencing Requirements

Accepted academic practice for referencing sources that you use in presentations can be found via the links on the Wattle site, under the file named “ANU and College Policies, Program Information, Student Support Services and Assessment”. Alternatively, you can seek help through the Students Learning Development website.

Returning Assignments

Assignments will be available for collection in the Drop In-Centre at the Research School of Chemistry, Building #137.

Extensions and Penalties

Extensions and late submission of assessment pieces are covered by the Student Assessment (Coursework) Policy and Procedure. The Course Convener may grant extensions for assessment pieces that are not examinations or take-home examinations. If you need an extension, you must request an extension in writing on or before the due date. If you have documented and appropriate medical evidence that demonstrates you were not able to request an extension on or before the due date, you may be able to request it after the due date.

Resubmission of Assignments

If the submission of a lab report is deemed unsatisfactory by the Course Convenor (on advice from the laboratory demonstrator), you may be asked to resubmit the report.

Privacy Notice

The ANU has made a number of third party, online, databases available for students to use. Use of each online database is conditional on student end users first agreeing to the database licensor’s terms of service and/or privacy policy. Students should read these carefully. In some cases student end users will be required to register an account with the database licensor and submit personal information, including their: first name; last name; ANU email address; and other information.
In cases where student end users are asked to submit ‘content’ to a database, such as an assignment or short answers, the database licensor may only use the student’s ‘content’ in accordance with the terms of service – including any (copyright) licence the student grants to the database licensor. Any personal information or content a student submits may be stored by the licensor, potentially offshore, and will be used to process the database service in accordance with the licensors terms of service and/or privacy policy.
If any student chooses not to agree to the database licensor’s terms of service or privacy policy, the student will not be able to access and use the database. In these circumstances students should contact their lecturer to enquire about alternative arrangements that are available.

Distribution of grades policy

Academic Quality Assurance Committee monitors the performance of students, including attrition, further study and employment rates and grade distribution, and College reports on quality assurance processes for assessment activities, including alignment with national and international disciplinary and interdisciplinary standards, as well as qualification type learning outcomes.

Since first semester 1994, ANU uses a grading scale for all courses. This grading scale is used by all academic areas of the University.

Support for students

The University offers students support through several different services. You may contact the services listed below directly or seek advice from your Course Convener, Student Administrators, or your College and Course representatives (if applicable).

• ANU Health, safety & wellbeing for medical services, counselling, mental health and spiritual support
• ANU Diversity and inclusion for students with a disability or ongoing or chronic illness
• ANU Dean of Students for confidential, impartial advice and help to resolve problems between students and the academic or administrative areas of the University
• ANU Academic Skills and Learning Centre supports you make your own decisions about how you learn and manage your workload.
• ANU Counselling Centre promotes, supports and enhances mental health and wellbeing within the University student community.
• ANUSA supports and represents undergraduate and ANU College students
• PARSA supports and represents postgraduate and research students