• Offered by Research School of Chemistry
  • ANU College ANU Joint Colleges of Science
  • Course subject Chemistry
  • Areas of interest Chemistry
  • Academic career UGRD
  • Course convener
    • Prof Thomas Huber
  • Mode of delivery In Person
  • Offered in Winter Session 2015
    See Future Offerings

Modern chemistry and biochemistry depends on the ability to make, change and analyse proteins and enzymes. This course focuses on the three-dimensional structures of proteins. It includes (I) the prediction of 3D structures by bioinformatic tools, (II) their analysis by X-ray crystallography, NMR spectroscopy and other techniques (e.g. chemical cross-linking and mass-spectrometry), (III) protein design, (IV) protein dynamics and folding and (V) structure-based drug discovery. The physical basis of the techniques will be discussed in depth. Wherever possible quantitative examples will be given – students will be expected to solve numerical problems. After completion of the course students will be able to view 3D structures of proteins, deduce properties from their structures and make structure-function predictions for mutants. The practicals associated with the course practice all of the steps required for the production of mutant proteins in E. coli in vivo and provide hands-on experience with bioinformatics tools and spectroscopic techniques of analysis.

Learning Outcomes

Upon successful completion, students will have the knowledge and skills to:

 

On satisfying the requirements of this course, students will have the knowledge and skills to:

1)    Capability to make mutant gene constructs, (LO-1)

2)    Capability to express proteins in vivo, (LO2)

3)    Capability to purify proteins from E. coli, (LO3)

4)    Ability to analyse proteins with spectroscopic analysis. (LO4)

5)    Detailed understanding of X-ray crystallography and NMR spectroscopy for 3D structure determination of proteins, (LO5)

6)    Understanding of structure-activity and dynamics-activity relationships of proteins, (LO6)

7)    Ability to use bioinformatics tools for the prediction of protein properties. (LO7)

8)    Capability to solve numerical problems associated with each course component. (LO8)

Indicative Assessment

50% by written exam, (LO 4,5,6 & 8)

50% by weekly assessments of practicals and tutorials (10 in total, 5% each). (LO 1- LO8)

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Workload

65 hours of lectures/tutorials/laboratory plus a further 65 hours of independent learning.

Requisite and Incompatibility

To enrol in this course you must have completed CHEM2208. You are not able to enrol in this course if you have previously studied CHEM3041.

Prescribed Texts

Recommended: Voet & Voet, Biochemistry (4th Ed.).  How Proteins Work. M.P. Williamson.

Majors

Specialisations

Fees

Tuition fees are for the academic year indicated at the top of the page.  

If you are a domestic graduate coursework or international student you will be required to pay tuition fees. Tuition fees are indexed annually. Further information for domestic and international students about tuition and other fees can be found at Fees.

Student Contribution Band:
2
Unit value:
6 units

If you are an undergraduate student and have been offered a Commonwealth supported place, your fees are set by the Australian Government for each course. At ANU 1 EFTSL is 48 units (normally 8 x 6-unit courses). You can find your student contribution amount for each course at Fees.  Where there is a unit range displayed for this course, not all unit options below may be available.

Units EFTSL
6.00 0.12500
Domestic fee paying students
Year Fee
2015 $3096
International fee paying students
Year Fee
2015 $4146
Note: Please note that fee information is for current year only.

Offerings, Dates and Class Summary Links

The list of offerings for future years is indicative only.
Class summaries, if available, can be accessed by clicking on the View link for the relevant class number.

Winter Session

Class number Class start date Last day to enrol Census date Class end date Mode Of Delivery Class Summary
1709 29 Jun 2015 03 Jul 2015 03 Jul 2015 10 Jul 2015 In Person N/A

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