What is cancer, and why is it a leading cause of death in many countries like Australia?  This course covers the Hallmarks of Cancer as described by Hanahan and Weinberg in their seminal papers of 2000 and 2011.  Normal cell biology and genetics and how it goes wrong in cancer will be presented, with principles being illustrated through clinically relevant examples. Classes will cover genetic, epigenetic, molecular biology, cell biology, cell signalling, immune, clinical and treatment aspects of cancer. Practicals / tutorials will also cover technologies and models used for studying cancer.

Learning Outcomes

Upon successful completion, students will have the knowledge and skills to:

On satisfying the requirements of this course, students will have the knowledge and skills to:

1. Explain the major hallmarks of cancer and the underlying molecular mechanisms.
2. Illustrate the hallmarks with specific examples.
3. Apply knowledge of the hallmarks to critically assess current and potential therapies.
4. Critically analyse experimental models used to study cancer.
5. Critically read a scientific journal article and present it in an appropriate scientific format.

Research-Led Teaching

BIOL6108 encourages students to develop a critical attitude towards science and to understand its evidence-based nature. Students will have opportunities to discuss case studies, problems and questions online. Contemporary and historical controversies in cancer will also be introduced providing the perspective necessary to understand how science and medicine have evolved.

BIOL6108 will be delivered by a team of lecturers who are currently actively engaged in cancer research in the area taught. Thus, they will not only present long-established facts about cancer, but also the latest research from their labs.

The practical component consists of experiments typically done in a cancer research laboratory. Providing the opportunity to become familiar with fundamental techniques and experimental strategies used to understand tumour initiation and progression and how this knowledge can be used to improve treatments for cancer patients.

Note: although hands on practical components will be modified in 2020 in accordance with COVID-19 restrictions, experience will still be gained in collating and interpreting both quantitative and qualitative cancer research data to generate laboratory reports.

Recommended Resources

The highly recommended textbook for BIOL6108 is:

The Biology of Cancer, (2nd Edition, 2013). Robert Weinberg. This will be available through the 2 hr reserve of the ANU library.

In addition, the previous edition will be available for 2 day loan from the library. Hard copies will be available for purchase from Harry Hartogs. The eBook can be purchased from Amazon for approximately $75.

Lecturers will refer to this text but will refer to additional resources made available in Wattle.

Staff Feedback

Students will be given feedback in the following forms in this course:

• written comments
• verbal comments
• feedback to whole class, groups, individuals, focus group etc

Student Feedback

ANU is committed to the demonstration of educational excellence and regularly seeks feedback from students. Students are encouraged to offer feedback directly to their Course Convener or through their College and Course representatives (if applicable). Feedback can also be provided to Course Conveners and teachers via the Student Experience of Learning & Teaching (SELT) feedback program. SELT surveys are confidential and also provide the Colleges and ANU Executive with opportunities to recognise excellent teaching, and opportunities for improvement.

Class Schedule

Week/Session	Summary of Activities	Assessment
1	3 Lectures, 1 Tutorial	e-Tutorial (Histology and Pathology of Cancer)
2	3 Lectures, 1 Tutorial	e-Tutorial (Tumour Viruses and Oncogenes)
3	3 Lectures, 1 Practical	Practical 1: e-Prac cBioPortal
4	3 Lectures, 1 Practical	Practical 2A: e-Prac
5	3 Lectures, 1 Practical	Practical 2B: e-Prac
6	3 Lectures, 1 Tutorial	e-Tutorial (Transformation and Immortality), Essay Topics Released
7	3 Lectures, 1 Tutorial, Annotated Bibliography Released	e-Tutorial (Angiogenesis + Lymphatics)
8	3 Lectures, 1 Tutorial	e-Tutorial (Invasion and Metastasis)
9	2 Lectures, 1 Tutorial	e-Tutorial (Tumour Immunology)
10	3 Lectures, 1 Tutorial	e-Tutorial (Drug Discovery)
11	3 Lectures, 1 Tutorial	e-Tutorial (Personalised Therapy)
12	3 Lectures	e-Tutorial (Exam Discussion). Essay due

Tutorial Registration

Sign up via Wattle

Assessment Summary

Assessment task	Value	Due Date	Return of assessment	Learning Outcomes
Multiple Choice Quiz for Computer Based Learning Practical	10 %	31/08/2020	*	1,2,3,4
Lab Report Practical 2	20 %	12/10/2020	*	1,2,3,4
Essay	20 %	28/10/2020	*	1,2,3,4
Annotated Bibliography	15 %	28/10/2020	*	1,2,3,4
Final Exam	35 %	05/11/2020	03/12/2020	1,2,3,4

* If the Due Date and Return of Assessment date are blank, see the Assessment Tab for specific Assessment Task details

Policies

ANU has educational policies, procedures and guidelines , which are designed to ensure that staff and students are aware of the University’s academic standards, and implement them. Students are expected to have read the Academic Integrity Rule before the commencement of their course. Other key policies and guidelines include:

• Academic Integrity Policy and Procedure
• Student Assessment (Coursework) Policy and Procedure
• Extenuating Circumstances Application
• Student Surveys and Evaluations
• Deferred Examinations
• Student Complaint Resolution Policy and Procedure
• Code of practice for teaching and learning

Assessment Requirements

The ANU is using Turnitin to enhance student citation and referencing techniques, and to assess assignment submissions as a component of the University's approach to managing Academic Integrity. For additional information regarding Turnitin please visit the Academic Skills website. In rare cases where online submission using Turnitin software is not technically possible; or where not using Turnitin software has been justified by the Course Convener and approved by the Associate Dean (Education) on the basis of the teaching model being employed; students shall submit assessment online via ‘Wattle’ outside of Turnitin, or failing that in hard copy, or through a combination of submission methods as approved by the Associate Dean (Education). The submission method is detailed below.

Moderation of Assessment

Marks that are allocated during Semester are to be considered provisional until formalised by the College examiners meeting at the end of each Semester. If appropriate, some moderation of marks might be applied prior to final results being released.

Participation

Formal registration of attendance is not taken however students are expected to attend lectures and workshops as well as contribute to discussions in-person and in the online forums throughout the semester.

Examination(s)

Final Exam

Value: 35%

To pass this course, you must achieve at least 50% overall and at least 45% on the final exam

Please note, that where a date range is used in the Assessment Summary in relation to exams, the due date and return date indicate the approximate timeframe in which the exam will be held and results returned to the student (official end of Semester results released on ISIS). Students should consult the course wattle site and the ANU final examination timetable to confirm the date, time and venue of the exam.

Assessment Task 1

Multiple Choice Quiz for Computer Based Learning Practical

Value: 10%

Assessment Task 2

Lab Report Practical 2

Value: 20%

Assessment Task 3

Essay

Value: 20%

Assessment Task 4

Annotated Bibliography

Value: 15%

Assessment Task 5

Final Exam

Value: 35%

Academic Integrity

Academic integrity is a core part of the ANU culture as a community of scholars. The University’s students are an integral part of that community. The academic integrity principle commits all students to engage in academic work in ways that are consistent with, and actively support, academic integrity, and to uphold this commitment by behaving honestly, responsibly and ethically, and with respect and fairness, in scholarly practice.

The University expects all staff and students to be familiar with the academic integrity principle, the Academic Integrity Rule 2021, the Policy: Student Academic Integrity and Procedure: Student Academic Integrity, and to uphold high standards of academic integrity to ensure the quality and value of our qualifications.

The Academic Integrity Rule 2021 is a legal document that the University uses to promote academic integrity, and manage breaches of the academic integrity principle. The Policy and Procedure support the Rule by outlining overarching principles, responsibilities and processes. The Academic Integrity Rule 2021 commences on 1 December 2021 and applies to courses commencing on or after that date, as well as to research conduct occurring on or after that date. Prior to this, the Academic Misconduct Rule 2015 applies.

 

The University commits to assisting all students to understand how to engage in academic work in ways that are consistent with, and actively support academic integrity. All coursework students must complete the online Academic Integrity Module (Epigeum), and Higher Degree Research (HDR) students are required to complete research integrity training. The Academic Integrity website provides information about services available to assist students with their assignments, examinations and other learning activities, as well as understanding and upholding academic integrity.

Online Submission

You will be required to electronically sign a declaration as part of the submission of your assignment. Please keep a copy of the assignment for your records. Unless an exemption has been approved by the Associate Dean (Education) submission must be through Turnitin.

Hardcopy Submission

For some forms of assessment (hand written assignments, art works, laboratory notes, etc.) hard copy submission is appropriate when approved by the Associate Dean (Education). Hard copy submissions must utilise the Assignment Cover Sheet. Please keep a copy of tasks completed for your records.

Late Submission

Individual assessment tasks may or may not allow for late submission. Policy regarding late submission is detailed below:

• Late submission not permitted. If submission of assessment tasks without an extension after the due date is not permitted, a mark of 0 will be awarded.

Referencing Requirements

The Academic Skills website has information to assist you with your writing and assessments. The website includes information about Academic Integrity including referencing requirements for different disciplines. There is also information on Plagiarism and different ways to use source material.

Returning Assignments

Practical reports will be marked online and available through Wattle. Test marks and answers will be available on Wattle.

Extensions and Penalties

Extensions and late submission of assessment pieces are covered by the Student Assessment (Coursework) Policy and Procedure. Extensions may be granted for assessment pieces that are not examinations or take-home examinations. If you need an extension, you must request an extension in writing on or before the due date. If you have documented and appropriate medical evidence that demonstrates you were not able to request an extension on or before the due date, you may be able to request it after the due date.

Resubmission of Assignments

No resubmission of assignments is permitted

Privacy Notice

The ANU has made a number of third party, online, databases available for students to use. Use of each online database is conditional on student end users first agreeing to the database licensor’s terms of service and/or privacy policy. Students should read these carefully. In some cases student end users will be required to register an account with the database licensor and submit personal information, including their: first name; last name; ANU email address; and other information.
In cases where student end users are asked to submit ‘content’ to a database, such as an assignment or short answers, the database licensor may only use the student’s ‘content’ in accordance with the terms of service – including any (copyright) licence the student grants to the database licensor. Any personal information or content a student submits may be stored by the licensor, potentially offshore, and will be used to process the database service in accordance with the licensors terms of service and/or privacy policy.
If any student chooses not to agree to the database licensor’s terms of service or privacy policy, the student will not be able to access and use the database. In these circumstances students should contact their lecturer to enquire about alternative arrangements that are available.

Distribution of grades policy

Academic Quality Assurance Committee monitors the performance of students, including attrition, further study and employment rates and grade distribution, and College reports on quality assurance processes for assessment activities, including alignment with national and international disciplinary and interdisciplinary standards, as well as qualification type learning outcomes.

Since first semester 1994, ANU uses a grading scale for all courses. This grading scale is used by all academic areas of the University.

Support for students

The University offers students support through several different services. You may contact the services listed below directly or seek advice from your Course Convener, Student Administrators, or your College and Course representatives (if applicable).

• ANU Health, safety & wellbeing for medical services, counselling, mental health and spiritual support
• ANU Access and inclusion for students with a disability or ongoing or chronic illness
• ANU Dean of Students for confidential, impartial advice and help to resolve problems between students and the academic or administrative areas of the University
• ANU Academic Skills and Learning Centre supports you make your own decisions about how you learn and manage your workload.
• ANU Counselling Centre promotes, supports and enhances mental health and wellbeing within the University student community.
• ANUSA supports and represents all ANU students